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Direction du Personnel Rue de Bruxelles, 61 B-5000 Namur Tél. : +32 (0)81 72 40 40 Fax : +32 (0)81 72 40 48 |
Le Conseil d'administration de
l'Université de Namur annonce la vacance du(des) poste(s) suivant(s) |
The “TumHyp” team of URBC from the University of Namur is recruiting a 4 year PhD student
Contract : fixed term contract
Category : scientific personnel
Allocation : External funds
Responsabilities
Research project: How cycling hypoxia initiates endothelial cell-macrophage cooperation to support tumor growth and metastasis The different tumor microenvironment components, both cellular like endothelial cells and tumor associated macrophages (TAMs), and physicochemical such as cycling or chronic hypoxia, all favor tumor development. Hypoxia initiates angiogenesis and the recruitment of monocytes, which will become TAMs. If these effects are now well described, few data are available regarding the reciprocal effects of TAMs on endothelial cells and angiogenesis, and of endothelial cells on TAM. Even less known is the influence of hypoxia, both cycling and chronic, on these parameters. The objective of this project is to study systematically the effects of both types of hypoxia on the inflammatory and angiogenic phenotype of TAMs and on their interplay with endothelial cells. In particular, we will focus on the influence of endothelial cells on the polarization of TAMs and the outcomes for cancer cell invasiveness and migration. Studies on murine tumor models as well as on human tumor biopsies will be developed in order to confirm in vitro results. All together, these results will allow to better understand the dialog between the different cell types present in tumors and of the consequences of these interactions on tumor growth and metastasis.
Profile
Qualification: Master 120 in Biochemistry or Cell Biology with a strong background in cancer biology and/or immunology. The candidate must be highly motivated, inquisitive and self-driven. He/she should be team-spirited since this project will be developed in close collaboration with Prof. O. Feron (UCL-Woluwé).
Additional information
Prof. Carine Michiels, URBC-NARILIS, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium, tel : +32-81-724131
Remarks
Financial support: This project is financed by a grant Télévie from the FNRS.
Procedure: Applications with a detailed CV and a letter of motivation should be sent to Prof. Carine Michiels (carine.michiels@unamur.be) before August 10, 2016
