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Allocation

PhD position in senescence and tumorigenesis

University faculty : Sciences
Department : Biology - URBC
Contract : fixed term contract
Category : scientific personnel

Responsabilities

A joint PhD position is available in the teams « Senescence, Fibrosis and Cancer » (UMR Canther) located at the Institut Pasteur de Lille (France) and « Stress and Ageing” (URBC-Narilis) located at the University of Namur (Belgium).

We are looking for a dynamic and highly motivated candidate to work on our collaborative project which aims to discover new pathways/targets with senolityc/senomorphic properties that would limit senescence/aging. We are particularly interested in understanding the role of an adaptive signalling pathway called Unfolded Protein Response (UPR) emanating from the endoplasmic reticulum (ER) in this process. The objectives of the project are to comprehensively characterize the functional role played by the UPR in senescence and senescence-associated secretory pathway (SASP), and to determine whether targeting specific branches of the UPR influences the pro-oncogenic SASP properties as well as age-related traits.

The project will use several approaches, including cell imaging, culture of primary cells, and in vivo experiments in mice. The project will involve a close cooperation with other biologists and bioinformaticians/biostatisticians, and will take place in highly competitive scientific infrastructures.

Profile

The candidates of any nationality should have a solid background in molecular and cellular biology (with experience in cell culture and cell signalling) and must hold a master degree in biology, biomedical sciences or equivalent. Practical experience of in vivo biological experimentation would be an asset.

Additional information

Florence CHAINIAUX

+32 (0)81 72 44 57

http://www.urbc.be/

Remarks

Candidates should send an application letter, a curriculum vitae, a brief summary of research interest, and two reference letters to: olivier.pluquet@ibl.cnrs.fr and florence.chainiaux@unamur.be before 26th February 2020.

The position will remain open until filled and is available from March 2020 for 42 months.